Animal Models of Ophthalmic Diseases by Chi-Chao Chan

By Chi-Chao Chan

This ebook describes experimental animal types that mimic universal human ocular ailments: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disorder, and intraocular tumors. In conjunction, those versions mirror the variety and software of instruments used to review human ailment. international professional clinicians talk about every one version in keeping with their scientific adventure and the textual content is supported via a number of pictures and diagrams. In describing the main pertinent animal types of ophthalmic illnesses, this ebook can be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and scientific students.

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Mol Vis 10:521–532 Manthey AL, Terrell AM, Wang Y, Taube JR, Yallowitz AR, Duncan MK (2014) The Zeb proteins deltaEF1 and Sip1 may have distinct functions in lens cells following cataract surgery. Invest Ophthalmol Vis Sci 55(8):5445–5455. 14-14845 Martinez-Wittinghan FJ, Sellitto C, Li L, Gong X, Brink PR, Mathias RT, White TW (2003) Dominant cataracts result from incongruous mixing of wild-type lens connexins. J Cell Biol 161(5):969–978. 200303068 Maruoka S, Matsuura T, Kawasaki K, Okamoto M, Yoshiaki H, Kodama M, Sugiyama M, Annaka M (2006) Biocompatibility of polyvinylalcohol gel as a vitreous substitute.

2011). Human γ-crystallin is encoded by six genes; CRYGA to CRYGF, encoding γA–γF-crystallin proteins. The γ-crystallins contain four Greek key motifs that fold to form higher order β-sheets, essential to maintain the transparent lens structure. Mouse models have been used to study the function of γ-crystallin through mutations. The first mutation in a γ-crystallin gene recorded was in the mouse Cryge gene called eye lens obsolescence (Elo) (Cartier et al. 1992). The Elo mutant is a dominant mutation that alters the reading frame of the fourth Greek key motif, thereby preventing the formation of the highly ordered crystallin structure.

21648 Li Q, Yan H, Ding TB, Han J, Shui YB, Beebe DC (2013) Oxidative responses induced by pharmacologic vitreolysis and/or long-term hyperoxia treatment in rat lenses. Curr Eye Res 38(6):639–648. 760741 Litt M, Kramer P, LaMorticella DM, Murphey W, Lovrien EW, Weleber RG (1998) Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA. Hum Mol Genet 7(3):471–474 25 Liu J, Hales AM, Chamberlain CG, McAvoy JW (1994) Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta.

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