By Marzio Pennisi, Francesco Pappalardo, Santo Motta (auth.), Paul S. Andrews, Jon Timmis, Nick D. L. Owens, Uwe Aickelin, Emma Hart, Andrew Hone, Andy M. Tyrrell (eds.)
This publication constitutes the refereed court cases of the eighth foreign convention on synthetic Immune platforms, ICARIS 2009, held in York, uk, in August 2009.
The 30 revised complete papers offered have been rigorously reviewed and chosen from fifty five submissions. The papers are geared up in topical sections on immune method modelling, theoretical elements of man-made immune structures, and utilized synthetic immune systems.
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Extra resources for Artificial Immune Systems: 8th International Conference, ICARIS 2009, York, UK, August 9-12, 2009. Proceedings
3, 53–60 (2005) 4.
In addition, Cytotoxic T Lymphocytes(CTLs) play vital role in controlling infection and variability of HIV-1. The pressure on HIV-1 progression is the Mathematical Model of HIV Superinfection and Comparative Drug Therapy 43 existence of either weak CTL selection pressure or viral mutations . A recent study shows that higher degree of immunodominance leads to more frequent escape with a reduced control of viral replication but a substantially impaired replicative capacity of the virus . We aim at modeling viral multi strain short and long term evolutionary dynamics especially transition of R5 to X4 phenotype switch and CTLs response.
To convince the reader of the benefits gained by adopting OO practices, this paper will justify and describe the refactoring in an OO way of immune models by tackling one of them: a very interesting model of cytotoxic T cell responses proposed by Chao et al some years ago . html although I have been told, discussing with Chao, that he were unaware of many researchers having moved on, modifying or extending the code. This very same frustrating situation could apply to another as much interesting immune modelling effort by Efroni, Cohen and Harel .