By Kenneth L. Kirk
Biochemistry of Halogenated natural Compounds has been written as a basic reference resource for researchers in different comparable components, together with natural chemists, medicinal chemists, pharmacologists, toxicologists, and clinical researchers. the advance of halogenated compounds as medicinal brokers and pharmacological instruments and the interesting biochemi cal tactics which have been came upon and studied utilizing those analogues have generated super lively components of study and a tremendous quantity of literature. hence, halogenated natural compounds pervade each point of biochemistry, a truth made obvious by way of the various reports and monographs on hand on person topics-halogenated nucleosides, halogenated carbohydrates, and so on. Given the volume of fabric already written on those themes, a few of which fabric is kind of present, it would be requested no matter if a one-volume evaluation of those matters turns out to be useful, or attainable. Having now accomplished this paintings, i believe the reply to either questions is an emphatic certain. There are interesting tales to be comparable in each one region, and, the place acceptable, i've got tried to strengthen those subject matters . from a ancient point of view. for instance, the invention of the anticancer job of fluorouracil, the unraveling of different mechanisms of its motion, and the improvement of a number of later generations of anticancer and antiviral brokers in line with the dad or mum fluoro-, iodo-, bromo-, and trifluoromethylpyrimidines have been, and are, contributions of significant importance to scientific science.
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Extra resources for Biochemistry of Halogenated Organic Compounds
Bioi. Chem. 247:2711-2716. Mariash, C. , and Schwartz, H. , 1986. Effect of dichloroacetate on rat hepatic messenger RNA activity profiles, Metabolism 35:452-456. Marietta, M. , Srere, P. , 1981. Stereochemical outcome of processing of fluorinated substances by ATP citrate lyase and malate synthase, Biochemistry 20:3719-3723. Marietta, M. , 1982. Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase, Biochemistry 21 :2637-2644. Meloche, H. , 1967. Bromopyruvate inactivation of 2-keto-3-deoxy-6-phosphogluconic aldolase.
Dichloroacetate in the treatment of lactic acidosis, Ann. Internal Med. 108:58-63. , 1988. , W. H. Freeman and Company, New York, pp. 379-382. , and Abeles, R. , 1977. Biotin carboxylations---concerted or nonconcerted? That is the question! J. BioI. Chern. 252:8338-8340. , and Abeles, R. , 1980. Are carboxylations involving biotin concerted or nonconcerted? J. BioI. Chern. 255:23&-242. Sullivan, A. , 1981. (- )-threo-Chlorocitric acid: A novel anorectic agent, Pharmacol. Biochem. Behav. 15:303-310.
1988. Kinetics of inactivation of creatine kinase during modification of its thiol groups, Biochemistry 27:5095-5100. Webb, 1. , 1966. Enzyme and Metabolic Inhibitors, Vol. III, Academic Press, New York, pp. 1-283. Welch, J. , 1987. Advances in the preparation of biologically active organofluorine compounds, Tetrahedron 43:3123-3197. , Cooper, R. , and Randle, P. , 1974. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids, Biochem. J. 141:761-774.