Cornea and External Eye Disease: Corneal by Thomas Reinhard, Frank Larkin

By Thomas Reinhard, Frank Larkin

This awesome quantity within the necessities in Ophthalmology sequence offers contemporary advancements within the analysis and remedy of corneal ailment. Its purpose isn't to switch the proper textbooks, yet to function a bridge among fundamental and tertiary literature. the peerlessly dependent quantity covers a dizzying array of issues together with Herpes simplex keratitis; amniotic membrane transplantation for the therapy of corneal ulceration in infectious keratitis; and Chlamydial an infection, all 3 of that are highly suitable this day. all of the issues have direct scientific value and won't purely maintain ophthalmologists modern, yet will tell them of the way to regard their cornea sufferers with optimum diagnostic and healing procedures.

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Additional resources for Cornea and External Eye Disease: Corneal Allotransplantation, Allergic Disease and Trachoma

Sample text

There is sound evidence that resident corneal cells, infiltrating polymorphonuclear neutrophils (PMN), and macrophages produce tissue-degrading enzymes. The matrix metalloproteinases (MMPs) are a family of protein-cleaving enzymes that degrade extracellular matrix and basement membrane components. Tissue inhibitors of metalloproteinases (TIMPs) are the major endogenous regulators of MMP activity in tissues. The expression of MMP-2, -9 and -8 increases markedly in the region of corneal ulceration and necrosis after HSV-1 infection.

Here, AMT can be considered after sufficient antibiotic treatment for at least 2–3 days. Kim and co-workers used AM in 9 patients with bacterial corneal ulcer. , n = 4, Pseudomonas, n = 5). The AM was placed after the patient received antibiotic therapy and clinical improvement was observed. In 7 of the 9 patients, the epithelium healed completely. In another patient, a stable corneal surface was noted and in the last patient neovascularization was reduced. Visual acuity improved in 7 of the 9 patients.

If the ulcer does not heal, gentle debridement of the loose epithelium and bandage contact lenses represent an additional treatment option. Temporary tarsorrhaphy, either by botulinum toxin-induced ptosis or suturing may be indicated. Whereas a conjunctival flap has historically been considered for treating nonhealing corneal ulcers, AMT is currently the preferred method. Lamellar or perforating keratoplasty is recommended for visual rehabilitation in patients with superficial or deep scar formation, when ulceration worsens, or when perforation is imminent.

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